Fucoidan, found in many species of brown seaweed, is a complex polysaccharide. It can prevent the growth of cancer cells plus it has immune-modulating and antiviral effects. The scientific literature on Fucoidan is growing rapidly mainly because of diverse biological activities on brown seaweed. Fucoidan can help prevent the growth of various cancer cells.

Low Molecular Weight:

Low molecular fucoidan is widely used as a supplementary food or as an artificial medicine. More than 200 patients have been receiving fucoidan in the clinic of Dr. Tachikawa Daisuke. Fucoidan has beneficial effects on patients with pancreatic problems. Colorectal cancer has also been treated with its help. A lot of these patients received this treatment during their radiotherapy. A dosage of 2-4g of fucoidan was given to these patients. Fucoidan helps in lowering the tumor size and also improves the quality of life. The responses of radiotherapy and chemotherapy are also enhanced with its help. Similarly, fucoidan increased the number of QOL’s.

Fucoidan with its low molecular weight helps hinder tumor angiogenesis with the regulation of HIF-1 signaling with hypoxia.

Synergistic Cancer Agent:

Fucoidan’s ability to work with other anti-cancer reagents has recently been discovered. The migration of multiple myeloma cells which are treated with chemotherapy drugs was affected by fucoidan. Fucoidan from Saccharina cichorioides has been found to synergize with the anti-tumor activity of low-dose resveratrol. In the colony formation assay, the colony number was reduced by 60% compared to 34% and 27% in resveratrol alone with help of fucoidan.

Colon cancer is also a very common cancer in the world. Vishchuk et al. applied fucoidan to the human colon cancer DLD-1 and found that it can inhibit tumor cell multiplication by suppressing the activity of epidermal growth factors. Kim et al. studied the effects of apoptosis. They found that apoptosis of colon cancer cells induced by fucoidan is regulated by the death of receptor-mediated apoptotic pathways.

Supplementary Usage:

In recent years, fucoidan has been used in cosmetics and animal-feeding supplements. It is also becoming major for dietary supplements usage. Fucoidan crude extract is mostly used in these studies which have an effect on the evaluation of bioactivities. There are new fucoidan-based pharmaceutical outputs being produced for cardiovascular disease treatment and judged for their human safety before they are used.

Fucoidan is applied in topical medications and in other possible dietary supplements. To evaluate fucoidan loss and to aid in production, new measuring techniques have been explained. Because of the dire need for antibiotic utilization in anti-pathogenic effects, alternative approaches are being used which are the major new applications of fucoidan.

Safest Seaweed:

Fucoidan is the safest brown seaweed polysaccharide. Beneath the walls of carefully selected seaweed, it is found. Almost all of the fucoidan consists of the same backbone structures but it mostly differs in the combination of its molecules. The composition of fucoidan depends mostly on the harvesting conditions. The majority of the studies suggest that fucoidan is beneficial for us in many ways and it helps in inflammation, carcinogen treatments, and oxidative stress.

In summary, fucoidan has great potential. More research will be conducted in the future to explore more of its mechanisms and functions in cancer treatments. In the future, fucoidan may become a favorable and natural anticancer therapeutic or auxiliary drug, opening a new direction for new anticancer drugs evolution. Similarly, more research will be done on its supplementary 

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